BSc Biochemistry Sem V 2017 18 2017-18 Bio Chem Immunology And Pathology I Question Paper - Mumbai University | munotes

Questions asked in this paper

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• 2. Figures to the right indicate full marks

1. Q3 All questions carry equal marks
2. Q4 Draw flowcharts
   • A) Choose the MOST APPROPRIATE option :(any three) 03
   • i) The physical barriers that form part of the immune system are
   • a) skin and all membranes
   • b) skin, body temperature and the peritoneal membranes
   • c) skin, body temperature and the mucosal membrane
   • ii) Neutrophils, eosinophils and basophils are
   • a) granulocytes
   • c) lymphocytes
   • iii) Innate immunity is provided by
   • a) Phagocytes
   • iv) Inflammation reaction is brought about by
   • a) cells
   • b) mast cells
   • c) macrophages
   • v) Memory cells are formed from
   • a) stem cells
   • b) monocytes
   • vi) Passive immunity is obtained through injecting $0125 /S0999 BIOCHEMISTRY : IMMUNOLOGY AND PATHOPHYSIOLOGY
   • Q.P. Code :20774
   • B) Define and explain any one of the following : 02
   • i) PALS
   • ii) Opsonin
   • C) Write note on any one: 04
   • i) Phagocytosis
   • D) Justify any one of the following: 06
   • i) Cytokines are chemical messengers mediating immune functions
   • ii) Cell mediated and humoral immunity are both mediated by 7;, cells
3. Q2 A) Choose the MOST APPROPRIATE option :(any three) 3 marks
   • i) ------------ has the highest avidity of the immunoglobulins
   • iii) Which is not.a function of
   • a) Major antibody in serum
   • b). First antibody type produced against an antigen during the primary antibody response
   • c) or fixes complement
   • iv) is present in
   • c) Only 2 fab
   • v) Heavy chains can be
   • vi) Within the antigen binding region ------------ shows lesser variability
   • a) hypervarible region
   • b). framework region $0125 /S0999 BIOCHEMISTRY : IMMUNOLOGY AND PATHOPHYSIOLOGY
   • Q.P. Code :20774
   • B) Define and explain any one of the following: 02
   • ii) Hapten
   • C) Attempt any one: 04
   • i) Write a short note on Monoclonal antibodies
   • ii) Justify : Antibodies are of more than one type
   • D) Answer any one of the following: 06
   • i) Elaborate on VDJ rearrangement in an antibody molecule
   • ii) Discuss the detailed structure of molecule
4. Q3 A) Choose the MOST APPROPRIATE option :(any three) 3 marks
   • i) The metal ion involved in atherosclerosis is
   • a) Cat?
   • ii) The oxidation state of iron in transferrin is
   • iii) is the subunit composition of
   • iv) Atheroma is
   • a). a fatty streak that increases elasticity of blood vessels
   • c) fat deposition that decreases elasticity of blood vessels
   • v) Gene involved in Von Gierke’s.is present on chromosome number
   • vi) disease is caused because of defective lysosomal enzyme
   • b) Tay Sach’s $0125 /S0999 BIOCHEMISTRY : IMMUNOLOGY AND PATHOPHYSIOLOGY
   • Q.P. Code :20774
   • B) Define and explain any one of the following: 02
   • i) Father of Biochemical genetics
   • ii) Haemoglobinopathy
   • C) Answer the following : (any one) 04
   • i) Explain the etiology and clinical manifestation of an inborn error of protein metabolism
   • ii) Discuss the underlying biochemistry and types of thalassemia
   • D) Answer the following : (any one) 06
   • i) In detail elaborate on an of carbohydrate metabolism, under the following
5. Q1 Etiology
6. Q3 Signs and symptoms
   • ii) Discuss in detail the sequence of events that lead to the progression of atherosclerosis
   • A) Choose the MOST APPROPRIATE option :(any three) 03
   • i) ---------------- is characteristic of cancerous cells
   • a) Increased synthesis of DNA and RNA
   • b) Have rounded shape
   • ii) is known as
   • a) sarcoma
   • b). glioma
   • c) leukemia
   • iii) P.53 is a
   • iv) cancers do not form a solid mass
   • b) carcinoma
   • c). sarcoma
   • v) The philadephia chromosome is associated with ---------------cancer
   • a) lymphoma
   • b) leukemia
   • c) myeloma $0125 /S0999 BIOCHEMISTRY : IMMUNOLOGY AND PATHOPHYSIOLOGY
   • Q.P. Code :20774
   • vi) BRCA — 1 is associated with ---------- cancer
   • a) breast
   • b) thyroid
   • c) nerve
   • B) Define and explain any one of the following: 02
   • i) Neoplasm
   • ii) Angiogenesis
   • C) Attempt any one: 04
   • ii) Discuss the physiology of cancer cells
   • D) Answer the following : (any one ) 06
   • i) Elaborate on the contribution of Ames to the field of cancer biology
   • ii) Discuss in detail the different treatment modalities available for cancer therapy
7. Q5 A) Answer any one : 3 marks
   • i) Give the biological. function (s) of : Iron binding proteins; Lysozymes; Paneth cells
   • ii) Differentiate between Innate and Adaptive Immunity
   • B) Attempt any one: 03
   • i) In short, explain factors affecting immunogenicity
   • ii) In relation to an antibody, describe the significance of sulfhydryl bond and hinge region
   • C) Answer the following : (any one) 03
   • i) Briefly explain.a disorder caused due to deficiency of iron
   • ii) Justify: “Sickle is caused due to a point mutation” Answer the following : (any one)
   • i) explain the significance of tumour suppressor gene, oncogenes and protoncoges in 03
   • ii) Differentiate between benign and malignant tumor State true or False any one: 03
   • i) All antigens are immunogens
   • ii) Molecular weight of chain is close to 150kD
   • iii) Clonal selection of cell involved in innate immunity is a way to ensure specificity
   • iv) Polyclonal antibodies are carcinogens
   • v) All mutagens are carcinogens
   • vi) errors of metabolism results due to autosomal recessive characters

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