BSc Biochemistry Sem V ATKT BIO CHEM BIOCHEMISTRY PAPER IV IMMUNOLOGY AND PATHOPHYSIOLOGY Question Paper - Mumbai University | munotes

Questions asked in this paper

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• 2. Figures to the right indicate full marks

1. Q3 All questions carry equal marks
   • A) Choose the MOST APPROPRIATE option : (any three) 03
   • a) Tears, breast milk, sweat, saliva, and faeces
   • ii) Macrophages are derived from
   • a) neutrophils
   • b) lymphocytes
   • c) monocytes
   • iii) Phagocytosis is not mediated by
   • a)~ kupffer cells
   • c) macrophages
   • iv) Active immunity is obtained through injecting
   • a) antibiotics
   • v) convey the longest lasting immunity to an infectious agent
   • c) acquired active
   • vi) -----=------- are most effective at destroying intracellular pathogens Paper Subject Code: 24107 Biochemistry : Paper IV - Immunology and Pathophysiology - I
   • Q.P. Code :20772
   • B) Define and explain any one of the following: 02
   • i) M cell
   • ii) Opsonization
   • C) Write note on any one: 04
   • ii) Cytokines
   • D) Answer any one of the following: 06
   • i) Compare and contrast — cell mediated immunity and humoral immunity
   • ii) Discuss the various cells involved in immune system
2. Q2 A) Choose the MOST APPROPRIATE option: (any three) 3 marks
   • i) ------------- is not True about antibody structure
   • a) Antibodies are built from equal numbers of large (heavy) and small (light) peptide chains
   • b) All antibodies are secreted and function away from the cell and they are not attached to the cell membrane
   • c) of the antibody molecule is determined solely by its heavy chain
   • ii) The antibody which is found in secretions is
   • iii) Light chains can be
   • iv) Within the antigen binding region ------------ shows maximum variability
   • a). hinge region
   • b) framework region
   • c) determining region
   • v) Proper hinge region is not present in ------------ antibody Paper Subject Code: 24107 Biochemistry : Paper IV - Immunology and Pathophysiology - I
   • Q.P. Code :20772
   • vi) Reagenic antibody has ------------- heavy chain
   • a) delta
   • b) mu
   • c) epsilon
   • B) Define and explain any one of the following: 02
   • ii) Immunogen
   • C) Write note on any one of the following: 04
   • ii) Types of chains present in antibodies
   • D) Answer any one of the following: 06
   • i) Elaborate on VJ rearrangement.in molecule
   • ii) Discuss the fine structure of an antibody molecule
3. Q3 A) Choose the MOST APPROPRIATE option : (any three) 3 marks
   • i) The oxidation state of iron.in Ferritin is
   • ii) is the subunit composition of
   • iii) Embolism is
   • a) fatty streak that increases elasticity of blood vessels
   • b) blood clot
   • c), clot that travels in blood
   • iv) Gene involved.in Tay Sach’s is present on chromosome number
   • v) anemia is the clinical manifestation of homozygous genes for an abnormal Hb molecule. The mutational event responsible for is
   • b) insertion
   • c) point Mutation Paper Subject Code: 24107 Biochemistry : Paper IV - Immunology and Pathophysiology - I
   • Q.P. Code :20772
   • vi) Spinach is not a good source of Iron because
   • a) ironis the inorganic form
   • b) it has high amount of oxalates
   • c) ironis an the organic form
   • B) Define and explain any one of the following: 02
   • ii) Arterioseclerosis
   • C) Answer the following: (any one) 04
   • i) Explain the etiology and clinical manifestation of an inborn error of carbohydrate metabolism
   • ii) Discuss the biochemical reason and pathophysiology of sickle cell anaemia
   • D) Answer the following: (any one) 06
   • i) In detail elaborate inborn — error of lipid metabolism, under the following headings:
   • a) Etiology
   • c) Signs and symptoms
   • ii) Discuss in detail the sequence of events that lead to the progression of atherosclerosis
   • A) Choose the MOST APPROPRIATE option : (any three) 03
   • i) 32—Year old woman has been diagnosed with her breast. Her aunt also suffers from breast cancer. Given this presentation, the patient is suspected to have a mutation in which
   • a) Ras
   • ii) Cancer of nervous tissue is known as --=
   • a), sarcoma
   • b) glioma
   • c) leukemia
   • iii) in humans is directly caused by a viral infection
   • c) Rous sarcoma
   • iv) a purine analog used in cancer therapy Paper Subject Code: 24107 Biochemistry : Paper IV - Immunology and Pathophysiology - I
   • Q.P. Code :20772
   • b) purine
   • v) Doctor says Skoog suffers from sarcoma. To the common man, Skoog suffers from cancer of
   • a) epithelial
   • b) bone
   • c) cartilage
   • vi) Cancer is caused due to
   • a) controlled mitosis
   • b) uncontrolled mitosis
   • c) uncontrolled meiosis
   • B) Define and explain any one of the following: 02
   • i) Metastasis
   • ii) Carcinogen
   • C) Answer the following: (any one) 04
   • i) Citing examples, explain physical and biological agents of cancer
   • ii) Discuss the morphological and biochemical characters of cancer cells
   • D) Answer the following: 06
   • i) Elaborate on a test to determine the mutagenicity of a chemical
   • ii) Write a detailed elaborative note on cancer therapy, with special emphasis on the use of
4. Q5 A) Answerany one: 3 marks
   • i) Give the biological of: complement system; phagolysozome; spleen
   • ii) Write a note on innate immunity Answer any one : 03
   • i) Write in brief about monoclonal antibodies
   • ii) Describe the effect of papain and mercaptoethanol on an antibody molecule
   • C) Answer the following : (Any one) 03
   • i) Briefly explain the etiology and types of albinism
   • ii) Justify: “Thalassemia is caused due to defect in globin chains”
   • D) Answer the following: (Any one) 03
   • i) Justify: “Cancer results because of defect in genes”
   • ii) State true or false, giving reason: “All cellular growths are cancerous” Paper Subject Code: 24107 Biochemistry : Paper IV - Immunology and Pathophysiology - I
   • Q.P. Code :20772
   • E) Answer the following : (Any one)
   • i) All immunogens are antigens
   • ii) Molecular weight of a heavy chain is close to 50kD
   • iii) Clonal selection of cells involved in adaptive immunity to ensure specificity
   • iv) Monoclonal antibodies are largely being used for cancer therapy
   • v) All carcinogens are mutagens
   • vi) Most in born errors of metabolism results due to autosomal dominant character

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