BSc Biotechnology Sem VI 2022 2023 Apr 2023 BIO TECH PHARMACOLOGY AND NEUROCHEMISTRY Question Paper - Mumbai University | munotes

Questions asked in this paper

• 1. Attempt all questions

1. Q2 All questions carry equal marks
2. Q4 Use of log tables and non-programmable calculator is allowed
3. Q1 a. Answer the following : (Any six) the term: Therapeutic index 6 marks
4. Q2 of EDTA form a complex with lead or arsenic is an example of which type of antagonism ?
5. Q3 What is the specificity of a drug ?
6. Q4 the efficacy ratio
7. Q5 What are receptors ?
8. Q6 What is the potency of a drug ?
9. Q7 Give one example of the study of effect of drug by quantal response curve
10. Q8 What is competitive antagonism ?
11. Q9 What is biophase ?
12. Q1 b. Answer the following questions: (Any Two) 14 marks
13. Q1 What are GPRS ? explain their role in in drug response
14. Q2 Explain giving suitable examples, non-competitive antagonism. Explain its effect on the drug response curve of an agonist
15. Q3 Explain giving suitable example the construction of a quantal dose response
16. Q2 a. Doas instructed: [MCQ] (Any six) 6 marks
17. Q1 Several drugs have an affinity for retinal pigment and thus may accumulate in the eye. The pigment is
    • a.melanin
    • b. xanthene
    • c. rhodopsin
    • d. carotenoid Stomach emptying time can be altered by
    • a.volume of ingested material
    • b. viscosity of ingested material
    • c. both
    • d. neither The closer the pKa of a drug to the tissue pH, diffusion of drug
    • a. will not be affected
    • b. will be slower across the membrane
    • c. will be faster across the membrane
    • d. will not take place
18. Q4 rate at which the drug reaches the site of action depends on
    • a. rate of intake
    • b. rate of absorption
    • c. rate of metabolism
    • d. rate of absorption and distribution
19. Q5 | overdose is given, neither can the drug be removed nor its absorption retarded. This route of drug administration is
    • a. Intravenous
    • b. oral
    • c. subcutaneous
    • d. intramuscular
20. Q6 The passage of the drug from its site of administration into the blood
    • a. Distribution
    • b. absorption
    • c. diffusion
    • d. adsorption
21. Q7 active efflux transporter in the blood brain barrier is
    • a. cytochrome p450
22. Q8 Since the pH of CSF is about 7.35, drugs which tend to concentrate in the
    • a. neutral drugs
23. Q9 The rate at which the drug penetrates the tissues and other body fluids
    • a. capillary permeability
    • c. both
    • d. neither
24. Q2 b. Answer the following questions: (Any Two) 14 marks
25. Q1 Explain selective accumulation of drugs in any three tissues
26. Q2 Elaborate on absorption of drugs from large intestine and rectum
27. Q3 Influence of pH on drug absorption and distribution of drug
28. Q3 a. Doas directed: (Any Six) 6 marks
29. Q1 the term: Toxicity
30. Q2 is an example of hypersensitivity
31. Q3 one example of the drug that causes pulmonary reaction
32. Q4 State true or false-Prolonged administration of Gold salts causes cancer
33. Q5 one example of the antidote given to cure methanol poisoning
34. Q6 | What do you mean by Drug Addiction?
35. Q7 one supportive treatment for accelerated elimination of the absorbed poison from the blood
36. Q8 Assign one antidote for lead poisoning
37. Q9 any one effect of phenoxy herbicide inhalation
38. Q3 b. Answer the following: (Any Two) 14 marks
39. Q1 Explain the term Misuse Drug. Elaborate- Alcohol as an Abused Drug
40. Q2 Discuss in detail the use of Supportive treatments being given to treat the
41. Q3 What do you understand by the term- Adverse Drug Reaction. Elaborate on any 3 elements attributing to the Adverse drug Reaction directed: (Any six) 06 Fill in the blank: The fatty acid sheath which surrounds and insulates most of the axons is called
42. Q2 any one role of autonomic nervous system
43. Q3 Name the neurotransmitter that regulates sleep-wake cycle
44. Q4 the neurotoxin produced by banded krait What is synapse?
45. Q6 Fill in the blank : several “islands” of gray matter, buried deep within the white matter of the cerebral hemispheres are called
46. Q7 Which region of the brain controls breathing?
47. Q8 Name any one compound that inhibits nicotinic receptors
48. Q9 Fill in the blank : Deficiency of L-DOPA causes
49. Q4 b. Discuss the following: (Any Two) 14 marks
50. Q1 Different types of synaptic vesicle proteins with their functions
51. Q2 Cerebrum with suitable diagram
52. Q3 Propagation of nerve impulses with suitable diagram Write Short notes on the following (Any four) 20
    • a. Measurement of drug safety
    • b. Drug distribution across the placental barrier
    • c. Absorption of drugs through skin
    • d. Adverse effects of the drugs on Male reproductive system
    • e. Electrical synapses
    • f. Cerebellum

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