BSc Biotechnology Sem VI 2018 19 Apr 2018-19 BIOTECH PHARMACOLOGY AND NUROCHEMISTRY Question Paper - Mumbai University | munotes

Questions asked in this paper

• 1. Attempt all questions

1. Q2 All questions carry equal marks
2. Q4 Use of log tables and non-programmable calculator is allowed
3. Q1 a. Answer the following objective questions as directed: (Any Six) 6 marks
4. Q1 Define
5. Q2 What is a ‘partial agonist’?
6. Q3 in the blank: shape is a characteristic of most drug —response curves when plotted on log scale
7. Q4 Fill in the blank: A drug is safer if it has (lower/higher) therapeutic
8. Q5 the term: The antagonism which involves a direct interaction between the agonist and antagonist to inactivate the agonist
9. Q6 Give the term used for: A comparative measure for drugs based the minimum quantity of a drug required to produce a given response
10. Q7 True or False: Reversible competitive antagonism is also termed as equilibrium
11. Q8 State True or False: Drug intrinsic activity is equivalent to drug affinity
12. Q9 Give one example of second messenger Explain the following questions: (Any Two) 14
13. Q1 Role of second messenger system in biological response to drugs
14. Q2 index' and illustrate how is it measured?
15. Q3 Pharmacological concept of “drug antagonism' with suitable examples
16. Q2 a. Doas directed: (Any six) State True or False: Intramuscular and subcutaneous routes include an increased reliability and precision in the drug blood level finally achieved and reasonably rapid absorption and onset of drug action 6 marks
17. Q2 True or False: The total volume of the fluid compartments of the body into which drugs may be distributed is approximately 40 L in a 70 Kg adult
18. Q3 one disadvantage of intravenous drug administration
19. Q4 What is lipid- water partition coefficient?
20. Q5 Give any one use of rectal drug administration
21. Q6 Give any one transport protein expressed in placenta and act as a
22. Q7 Give one example of pathological factor for increased gastric
23. Q8 Fill in the blank: acts as a barrier in drug penetration of the skin (Stratum
24. Q9 in the blank: The surface are of the pulmonary alveolar membranes is
25. Q2 b. Discuss the following questions: (Any Two) 14 marks
26. Q1 Absorption of drugs in oral cavity and small intestine
27. Q2 Role of plasma binding proteins in drug absorption
28. Q3 With reference to physiological barriers
29. Q3 a. instructed: (Any Six) What is toxicology? 6 marks
30. Q2 is alcoholism? Give one example of drug used during interrogation is heroine obtained from?
31. Q5 Name any one main category of toxicology
32. Q6 What is the role of the consumer product safety commission?
33. Q7 for State True or False: The Food and Drug Administration (FDA) is responsible for allowing drugs, cosmetics, and food additives to be sold in the market according to the Federal Food, Drug and Cosmetic Act (FDCA)
34. Q9 State True or False: Thalidomide is a safe drug during pregnancy
35. Q3 b. Answer the following questions: (Any Two) 14 marks
36. Q1 Enlist any seven principle clinical manifestation of allergic reactions
37. Q2 Discuss the adverse effects of drugs on reproduction
38. Q3 What is drug abuse? Discuss with any one example
39. Q4 a. Attempt the following objective questions as instructed: (Any Six) 6 marks
40. Q1 What is Neuromuscular junction?
41. Q2 Define Boutons
42. Q3 Name any one anesthetics
43. Q4 Synaptic cleft
44. Q5 What is Action potential?
45. Q6 Write any one function associated with midbrain
46. Q7 Name any one effect of scorpion toxin on channels
47. Q8 Name any one neuroinhibitor in spinal cord and brainstem
48. Q9 the one hexameric protein, which forms gap junction
49. Q4 b. Answer the following questions: (Any Two) 14 marks
50. Q1 Explain in detail about synapses and its types
51. Q2 Diagrammatically explain the organization of brain
52. Q3 Briefly explain neuronal excitation Write Short notes on the following: (Any four) 20
    • a. Chemistry of drug—receptor binding
    • b. Metabolism and efflux transporters affecting rate of gastro-intestinal
    • d. Neurotoxins
    • e. Methanol poisoning

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