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B.Sc. (Biotechnology) Genomics and Proteomics Syllabus - Mumbai University 2026

This is the TY BSc Biotechnology syllabus under NEP 2020, in force from the academic year 2026-27. The University still examines the earlier Choice Based papers alongside it — her third-year office registers name that scheme — so check which scheme your exam form names before you revise.

Genomics and Proteomics Syllabus.pdf
Major · Semester 5 · TY BSc Biotechnology · 2 credits · 50 marks

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Syllabus for Genomics and Proteomics

Major · Semester 5 · TY BSc Biotechnology · 2 credits · 50 marks

Module I: Genomics

  • Genetic Engineering in Plant: Ti plasmid structure; vir genes and mechanism of T-DNA transfer and integration. Co-integrate and binary vector systems; Selection and regeneration of transformed plant tissues. Microprojectile bombardment. (4 Lectures)
  • Genetic Engineering in Animal: Transgenic Animal: Electroporation, DNA microinjection method. Targeted Gene Manipulation – Cre–loxP recombination system (3 Lectures)
  • Molecular Techniques in Genomic: Transcriptome and Genome
  • Analysis: Southern blotting; Northern blotting. PCR-Based Gene
  • Expression RT-PCR: synthesis of cDNA using reverse transcriptase;
  • Application of RT-PCR Sanger’s dideoxy sequencing method: Principle, workflow. (5 Lectures)
  • AI in genomics, proteomics and bioinformatics: Introduction, The role of AI in bioinformatics : Prediction of molecular interactions, drug discovery and modeling (Omics : Genomics, Transcriptomics, Epigenomics, Proteomics, Metagenomics), Phylogenetic assessment, Systems biology. AI and personalized medicine. Medical visual data (Biomedical imaging, Signal processing, Biomedical text mining). (3 Lectures)

Module II: Protein Biochemistry and Proteomics

  • Levels of Protein Structure: Primary and secondary, Tertiary and quaternary structure; Relationship between protein structure and biological function. (2 Lectures)
  • Post-Translational Modifications (PTMs): Types of PTMs (phosphorylation, glycosylation and acetylation); Biological significance and functional implications of PTMs. (3 Lectures)
  • Introduction to Proteomics: Definition of proteomics; Types of proteomics: expression, structural and functional proteomics; Comparison between proteomics and genomics. (1 Lecture)
  • Protein Identification and Characterization: Protein digestion methods with emphasis on enzymatic digestion; Edman degradation method, Principles of mass spectrometry; Ionization techniques: MALDI and ESI; Mass analyzers: TOF, Quadrupole and Ion Trap; Peptide mass fingerprinting (PMF); Tandem mass spectrometry (MS/MS). (7 Lectures)
  • Applications of Proteomics: Clinical proteomics; Biomarker discovery; Drug discovery and development; Applications of proteomics in cancer and infectious diseases. (2 Lectures)

Textbooks

  • 1 Watson, J. D., Baker, T. A., Bell, S. P., Gann, A., Levine, M., & Losick, R. Molecular Biology of the Gene. Pearson Education.
  • 2 Primrose, S. B., & Twyman, R. M. Principles of Gene Manipulation and Genomics. Blackwell Publishing.
  • 3 Srivastava, S. (2023). From Proteins to Proteomics: Basic Concepts, Techniques, and Applications. CRC Press. Weblinks:
  • 1 https://pmc.ncbi.nlm.nih.gov/articles/PMC11413381/
  • 1 Brown, T. A. Genomes. Garland Science.
  • 2 Pennington, S. R., & Dunn, M. J. Proteomics: From Protein Sequence to Function. BIOS Scientific Publishers.
  • 3 Twyman, R. M. Advanced Molecular Biology. Garland Science.
  • 4 Chapman, J. Protein and Proteomics, Elsevier
  • 5 Glick, B. R., Pasternak, J. J., & Patten, C. L. Molecular Biotechnology: Principles and Applications of Recombinant DNA. ASM Press.
  • 6 Dunn, M. J. Proteomics: Advances in Protein Chemistry, Academic Press
  • 7 Alberts et al. Molecular Biology of the Cell, Garland Science
  • 8 Twyman, R. M. Principles of Proteomics, Garland Science
  • 9 Lovrien, R. Proteomics: Methods and Protocols, Humana Press Weblinks :
  • 1 https://www.thermofisher.com/in/en/home/life-science/cloning/cloning- learning-center/invitrogen-school-of-molecular-biology/next-generation- sequencing/illumina-workflow.html

Reproduced from the University of Mumbai syllabus for B.Sc. (Biotechnology) under NEP 2020, in force from the academic year 2026-27. Wording is as printed in that syllabus. Module numbering is as printed there too.

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